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Posted: 23-01-2002 22:21 Post subject: Longer life span.

It seems our decendents may be in for a longer life span in the not too distant future,click here for full story.

Posted: 23-01-2002 23:08 Post subject:

Well, my great gran lived into her nineties. My grandad's still going strong in his nineties. My other grandparents made it to 79, early 80's and late 80's. Barring pit collapses and wars, my family seems to be doing okay, so I don't worry too much Smile

Posted: 23-01-2002 23:24 Post subject:

It would be great to discover a gene for a 'interesting' life. Many people seem to reach a great age despite having led very dull lives.

But I suspect that an 'interesting' gene would also lead to a shortened life - as the old saying goes, there are old pilots, and bold pilots, but NO old, bold pilots!

Posted: 24-01-2002 00:36 Post subject:

I think there is some evidence that a restricted calorific diet in youth
is the best indicator of longevity. Bad news for today's obese teens.

I do hope it isn't parental lifespan. I had mine murdered for starving me.
:p

Posted: 24-01-2002 01:21 Post subject:

I suggest we keep an eye on the price of this compound. It is a very simple one (judging by its generic name) and if the price goes through the roof ....

BTW I made a prediction a couple of years ago that given the current demographic changes in this country (pensioned/non-pensioned) that the retirement age would start to go up. Something like this would accelerate such a trend.

Last edited by Guest on 11-06-2002 08:29; edited 1 time in total

big news for all interested in real methods for stopping aging. A new biotech company has been started by one of Geron's staff, for the purpose of studying ways to activate the telomerase gene...thus repairing the tips of our DNA...and ending aging. hopefully.

SIERRA .....sierrasci.com....dr. andrews' new company is at sierrasci.com, and i highly recommend that u visit the site.

FROM MORTAL TO IMMORTAL......if u read the geron paper on the immortalization of two of their cell lines by having telomerase spliced in....then u will understand the great promise of this line of research. No cancerous tendencies were seen in these two cell lines.

EDITING TO ADD;...grg.org...... Also favoring immortalization, free of cancer, are two related facts. One, some whales live over two hundred years, so mammals can beat the human "limit" without a cancer barrier. I believe it is the bowhead whale, age determined by eyelens deterioration rate. try grg.org, news button, for details.

Two, nonmammals give even more hope...we all know of the bristlecone pine and creosote bush, which i vaguely recall as being in the high hundreds at least. DNA can live long, free of cancer.

This (Sierra) is the biggest news for the antiaging field in the last few years.
John Newtol
the sites again:...sierrasci.com and on whales, ...grg.org..their news button

Posted: 08-06-2002 16:19 Post subject:

Telomerase is a pretty ingenious enzyme. But from the lectures ive had i thought they had tried to increase telomerase in knock-in mice and this led to increased cancer. The theory being that extending the chromosomal lifetime by increasing telomerase activity interfered with the tumor suppressor genes allowing cancer to go unchecked. What has been done differently to avoid this?

Posted: 08-06-2002 20:51 Post subject:

If we live for ever, we'll never get to heaven!

Posted: 08-06-2002 21:03 Post subject:

And who will pay your pension forever?

Posted: 09-06-2002 05:13 Post subject: immortality

CANCER FREE EVIDENCE ADDITION;.. DNA can live long, free of cancer..bowhead whales, ovr two hundred years, and bristlecone pines, creosote bushes, in the high hundreds at least. see grg.org, news button for details.

thanks for the replies.....as to pension, pete, if one is truly youthful, as one study reversing aged fibroblasts suggests, then one continues working and no pension needed.
as to a study on knockin mice, pls supply definition of knock in . familiar with knock out, ....are knock ins those plus restored telo. gene? If so, Sierra reports at site, that such mice in a two thousand one study had premature aging reversed...no mention of any downsides. Can u pls.reference the study you recall?
In any event, cancer free cells with active telomerase genes, were reported by geron in about 1998. So perhaps the current situation is one of conflicting studies viz cancer. In that case, hope exists, and more experiments will possibly delineate just how to avoid any cancers, whilst gaining the immortality that telomerase has demonstrated in the Geron study. I remain convinced of one thing...this area deserves intense study, and vastly more funding than it is getting. The stakes are high, but sadly most people can't even imagine an end of death.....so such research gets paltry funding.
John Newtol

Posted: 09-06-2002 07:48 Post subject:

You could still die,though, just not naturally. It doesn't grant invincibility. Maybe someone
should start up an organization that is responsible for gathering donations and raising
public awarness of the research, if it hasn't already been started??

Posted: 09-06-2002 08:00 Post subject:

There would be no need for children - in fact reproducing might have to be banned to prevent over population.

That would put schools and teachers out of business, not to mention midwives, toy manufacturers, etc, etc. (On the plus side, greedy undertakers would be out of work too!)

A world without children? Sounds like a bad thing to me.

And what happens to the minds of people who live forever? If they just get more set in their ways then the world would be very dull and boring. We need new people and new ideas.

Dangerous research, methinks. But then of course, the people as a whole will never get this treatment - it will be reserved exclusively for the rich and powerful. As if we don't have enough problems with them already, now they'll live forever!

We must take action now! Burn down all Geron's premises - NOW!

Posted: 09-06-2002 14:45 Post subject: RYNNER, THANKS

hmmmm....food for thought . thanks, rynner, bane of skep.
..rynner, i have corrected my misspelling of ur name here, but poss not everywhere in this post..sorry.

now...as to end of repro and kids., there is the space elevator,coming in five yrs, with carbon nanotubles fm japanese factories...see unknowncountry.com.
this will make settling space very cheap, so excess pop. will never again be a problem.

job loss? no, healthies will need more sports equip and cars, etc, so new expansion there.

as to set in their ways....hmmmm...must think about that one. score one, rhymer.

as to who will get it, i imagine that seeing the few get such a great thing , will excite a huge push by the many to also get it. Like free health care, only much much more so. ps....do u get free RX pills over in brit?
Besides, are u really willing to die, on the mere possiblity that in the unformed future, u GUESS immortality will not be widely distributed? At least , get it on the shelf, now, and later worry about getting some yourself. i am not saying ur needs are unimportant, i am saying dont abandon your possibllities by not pushing to at least get immort. on the shelf.

LEAD TIME FOR THE RESEARCH.......getting it on the shelf is something that takes time, and u have no time to waste in such matters. the grim reaper's clock is ticking on us all. You could find out tomorrow that u have pancreatic cancer.
Cordially,
John Newtol

Posted: 09-06-2002 18:02 Post subject:

What are RX pills? Where is brit? Who is rhymer? confused

Posted: 09-06-2002 20:07 Post subject: RYNNER, NOT RHYMER

sorry, got his name wrong...fuzzy monitor here.....rhymer is really rynner or rynnr.

RX is prescription pills.

brit is britain...wherebe ye, ol chap?

I be residing in new orleans, six time zones west of the big observatory that anchors the sway of time.

CURE FOR RYNNER'S PROBLEM OF OLDSTERS 'SET IN THEIR WAYS'

well, i dont have a clear answer, but if it becomes truly a major problem, society will allocate more resources to curing it,.....thus a cure will ensue .
I propose as tentative beginnings, these, from mildest to strongest:

Travel, art

Prescription pills and roots

Transcranial Magnetic Stimulation
....TMS...which is now being used experimentally in mainstream universities to alter brain function, without surgery.
not otc magnets, mind u, but massive ones.

Use of PET scans to pinpoint the nerve bundles involved in loss of creativity of youth. Then, careful surgical intervention, withpossible removal of the problem neurons, and replacement with youthful, autocloned neurons. in time, this may become as routine as heart transplant is today.

Overall, it is better to choose immortality and be alive to work on this problem, than to choose to be dead, working on nothing.
John Newtol